Evidence methodology

Source hierarchy

Sources are ranked; a claim cites the strongest available and labels the type.

1. FDA-approved labeling
2. Regulator or agency guidance
3. Professional guideline
4. Peer-reviewed human evidence
5. Registered clinical trial record
6. Observational human evidence
7. Animal or in-vitro evidence
8. Manufacturer information

Forums, influencer content, retailer pages, and community claims are never sources for published claims.

One status per entry

• FDA-approved product or use context. Refers to an FDA-approved labeling context. Approval is specific to product, route, and indication.
• Compounded product context; not FDA-approved. Compounded preparations are not FDA-approved and are not evaluated for safety, effectiveness, or quality by the FDA.
• Investigational. Studied in registered trials or research; not approved for general use.
• Research-only; not for human use. Sold or described for laboratory research only. Not approved or intended for people.
• Supplement or non-drug context. Regulated as a supplement or non-drug product; claims are not evaluated like drug labeling.
• Status unknown or not reviewed. No reviewed status is available for this entry.

Claim-level citations

Each claim stores its text, source, exact locator, evidence type, route and population context, reviewer, review date, next review date, and whether it has been superseded or retracted. You can open the source behind any consequential claim.

Review and versions

Drafts are written by an administrator, reviewed by a designated reviewer who did not write them, and published as a numbered version. Edits never change a live version until re-reviewed and republished. An emergency unpublish takes effect immediately and keeps history. Apps stop presenting withdrawn or superseded content as current.

Language

Entries describe context, evidence, and uncertainty. They do not tell you what to take, how much, or what to do about a missed item. Educational, not medical advice.